Our lab is interested in understanding and exploiting the contribution of bioenergetics to neural stem cell (NSC) fate in the adult brain. By bridging areas of stem cell biology and metabolism, we aim to discover checkpoint mechanisms and promising molecules capable of improving the neuroregenerative potential of these cells throughout adulthood. The process of generating new neurons from NSCs is critical for sustaining cognition and mental health but it is severely hampered with ageing and neurodegenerative disorders. Our team aims to uncover the mechanisms by which NSCs contribute to the homeostatic control and regeneration potential of the brain. We are particularly focused on unraveling molecular aspects related to the comorbidity of metabolic dysfunction and neurological disorders. Specifically, in understanding how the individual metabolism, driven by physical activity, nutritional habits, and gut microbiome, affects NSC-mediated neuroplasticity. We are interested in combining our findings with non-invasive and innovative strategies to increase the endogenous protection of NSCs throughout life and prevent a wide range of neurological problems. This will ultimately help to improve the well-being and life quality in later adulthood and old age populations.
Stem Cell Bioenergetics and Neuroregeneration
