Microphysiological systems have emerged to provide an alternative to in vivo models in basic science and pharmaceutical research. In this group, we seek to understand how physical properties and biochemical cues work together to regulate and modulate cell functions. Ultimately, we aim to generate the grounds for more personalized/indication-specific treatments. Alternative Cell Models in Toxicology The poor predictability of human liver toxicity is still causing high attrition rates of drug candidates in the pharmaceutical industry. Herein, we strategically recreate the microphysiological (3D) environment for the development of relevant in vitromodels (e.g. liver) to study bioactivation and toxicity of xenobiotics, including drugs and environmental carcinogens. Tissue Engineering & Regenerative Medicine In this research area we explore 3D models of human stem cells for personalized cell-based therapy applications (liver diseases, skin regeneration, rheumatoid arthritis), and the development of new ATMPs. Cells-derived secretome/exosomes, and their paracrine effects, are also exploited towards cell free-based therapies.
Advanced Cell Models for Predictive Toxicology & Cell-based Therapies
